摘要
目的比较0.03%他克莫司软膏外用和得宝松注射液皮损内注射对口腔扁平苔藓患者的疗效、不良反应和复发率。方法选择口腔扁平苔藓患者60例并随机分成2组。治疗组用0.03%他克莫司软膏2次/d皮损处外用,连续4周;对照组皮损局部应用得宝松2周1次连续注射4周治疗。按REU评分评价4周后疗效、不良反应和治疗结束后随访4周复发率。结果治疗组有效率为69.33%,对照组有效率为79.31%;治疗组复发率为5.26%,对照组复发率为4.37%,两组疗效及复发率差异无统计学意义(P>0.05)。治疗组不良反应率低于对照组(13.33%vs 34.48%,P<0.05)。结论 0.03%他克莫司软膏外用与得宝松注射液皮损内注射治疗口腔扁平苔藓均有良好的临床疗效,他克莫司乳膏更为安全。
Objective To compare the efficacy, adverse reactions recurernce rate of 0. 03% tacrolimus ointment with diprospan injection in the treatment of oral lichen planus patients. Methods A total of 60 patients were divided into two groups randomly. 30 cases were treated with 0. 03 % tacrolimus ointment twice daily （treatment group） , and 30 cases were treated with intralesional diprospan injection once every two weeks（ control group）, The efficacy and adverse reactions were graded after 4 weeks. The recurrence rate was evaluated in the following 4 weeks. Results The efficacy rate were 69. 33 % and 79. 31% in treatment group and control group respectively, and the recurrence rate were 5.26% and 4. 37% ,the adverse reactions rate were 5.26% and 4. 37%. There was no obvious difference in the curative rate and recurrence rate （ P 〉 0. 05 ）. Conclusion Topical 0. 03% tacrolimus ointment and diprospan injection both induced a better initial therapeutic response and less recurrence in oral lichen planus, and the former will be safer.
出处
《实用药物与临床》
CAS
2013年第10期924-925,共2页
Practical Pharmacy and Clinical Remedies
