摘要
狂犬病是重要的人兽共患疾病,在我国,每年约有2000～3000人死于狂犬病。固有免疫是机体针对病毒等病原的第一道非特异的防线,同时,也对特异性的获得性免疫应答产生影响。目前,固有免疫中RIG-I通路及其抗病毒作用机制研究深入广泛。狂犬病病毒进化中获得诸多针对宿主特别是固有免疫应答的逃逸机制,针对该机制的研究对于狂犬病的预防、诊断及治疗具有重要意义,同时,也为其他病毒的免疫逃逸相关研究奠定基础。
Rabies is an important zoonosis which cause about 2000 ～ 3000 deaths in China every year. Innate immunity is the first nonspecific defense of host against exotic pathogens including viruses, which influences the specific adaptive immune responses. At present, RIG-I pathway in innatity immunity and its antiviral functional mechanisms are investigated deeply and widely. During evolution, rabies virus has acquired many evading mechanism against host, especially those against innate immunity. The research related to immune evading mechanism of rabies virus plays akey role in the prevention, diagnosis and treatment of rabies, which lays a foundation of study on immune evading of other viruses.
出处
《中国生物制品学杂志》
CAS
CSCD
2013年第10期1517-1521,共5页
Chinese Journal of Biologicals
基金
国家863计划项目(2011AA10A212)
