摘要
哺乳动物雷帕霉素靶蛋白(mammalian target of rapamycin,mTOR)是一种丝/苏氨酸蛋白激酶,在调节细胞的生长、增殖和存活中起着重要的作用。mTOR复合体调控mRNA的转录、核糖体的合成及代谢相关基因的表达,通过磷酸化其下游的靶蛋白如S6蛋白激酶和4E-BP1等来调节细胞的活动。近年来,mTOR分子及其相关信号通路在衰老调控中所起的作用渐渐被人们所认识。对mTOR信号通路在衰老中的生物学功能和调节机制的研究,不仅可以深入了解细胞自我更新和分化的机制,而且对衰老及其相关疾病的治疗、预防及寻找潜在的治疗靶点与药物具有重要意义。本文主要介绍mTOR信号通路在造血系统及其他系统衰老中研究的最新进展。
Mammalian target of rapamycin（mTOR） is a serine/threonine protein kinase, which plays an essential role in cell growth, proliferation and survival, mTOR regulates the transcription of mRNA, synthesis of ribosome and gene expression for metabolism. By forming mTOR complex, it regulates cellular activities by phosphorylating its downstream proteins, such as S6 protein kinase and 4E-BP1. In recent years, the role of mTORC1 in regulating aging is gradually recognized. Studies of physiological function and the regulatory mechanisms of mTOR signaling can not only help to better understand the aging mechanism for ceils or organs, but also provide insights as to finding potential new drug targets for aging related diseases. This review focuses on recent advances of roTOR and aging related diseases in hematopoietic and other organ systems.
出处
《中国实验血液学杂志》
CAS
CSCD
北大核心
2013年第5期1313-1317,共5页
Journal of Experimental Hematology
基金
科技部973项目(编号2012CB966604,2010CB945204)
科技部重大国际合作项目(编号2010DFB30270)
国家重大医药专项项目(编号2011ZX09102-010-04)
国家自然科学基金项目(编号81090410,81130074,30825017)
