摘要
[目的]研究痛宁凝胶的经皮渗透性,并考察7%Transcutol P和0.5%Labrosal对痛宁凝胶在大鼠体内经皮渗透性的影响。[方法]应用经皮微渗析在体取样技术,以SD大鼠为模型进行实验。在体回收率采用反向渗析法测定。[结果]反向渗析法测定的在体回收率对照组为(57.8±5.09)%,7%Transcutol P组为(53.02±1.25)%,0.5%Labrosal组为(46.57±0.49)%,渗析液中的药物的稳态流量(Js)分别为1.06、11.38、2.28 ng/h,滞后时间(T lag)分别为-0.32、0.75、0.25 h。[结论]7%Transcutol P能极大提高药物在渗析液及皮肤中的浓度,适合经皮给药,可进一步应用于痛宁凝胶制剂中。
[Objective] To study the transdermal absorption of Tongning gel in rats with or without the widely used enhancer 7% Transcutol P and 0.5% Labrosal. [Methods] Using in vivo transcutaneous sampling technique with micro-dialysis and taking SD rats as the model the experiment was performed. The recovery rate in vivo was assessed with retrograde microdialysis probe.[Results] The in vivo recovery of the control, the 7%Transcutol P and the 0.5%Labrosal was 57.8%±5.09%, 53.02%±1.25% and 46.57%±0.49% respectively. The steady state flux of Tetrahydropalmatine in dialysate （Js） was 1.06, 11.38 and 2.28 ng/h respectively. The lag time was -0.32, 0.75 and 0.25 h. [Conclusion] The concentrations of tetrahydropalmatine in the dialysate and the dermis are increased greatly by 7% Transcutol P. So this preparation is suitable for transdermal drug delivery, and is likely to apply in the preparation of the Tongning gel.
出处
《天津中医药》
CAS
2013年第10期618-620,共3页
Tianjin Journal of Traditional Chinese Medicine
基金
国家重点实验室开放基金项目(SKL2010M0301)
关键词
微渗析
痛宁凝胶
促渗剂
经皮吸收
延胡索乙素
microdialysis
Tongning gel
penetration enhancer
transdermal delivery
tetrahydropalmatine
