摘要
目的:观察健肝颗粒联合经导管动脉栓塞术(transcatheter arterial chemoembolization,TACE)治疗HBV DNA阳性原发性肝癌(HCC)的效果及其预后。方法:HBV DNA>103IU/ml的HCC患者126例,均予核苷类似物药抗病毒治疗,并随机分为TACE联合健肝颗粒的治疗组(62例)和TACE治疗的对照组(64例),观察两组患者肝功能Child-Pugh评分、HBV DNA定量、实体瘤体积变化和两年生存率。结果:治疗两年后,治疗组患者肝功能ChildPugh评分较对照组降低,且治疗组患者两年生存率比对照组高,其差异均有统计学意义(P<0.05);实体瘤缩小和HBV DNA定量变化两组比较差异无统计学意义(P>0.05)。结论:健肝颗粒联合TACE治疗可改善HCC患者的肝功能,提高其生存率和生活质量。
Objective: To investigate the efficacy of the addition of the Jian-gan granules to transcatheter arterial chemoem- bolization (TACE) in patients with hepatitis B virus HBV DNA-positive hepatocellular carcinoma (HCC) who received antiviral therapy with nucleoside analogues. Methods: One hundred and twenty-six HCC patients with HBV DNA 〉 10^3IU/ml were included. All patients received antiviral therapy with nucleoside analogues. Then they were randomly assigned to receive TACE alone (n = 64 ) or in combination with the Jian-gan granules (n = 62) . Two-year survival and changes in Child-Pugh scores, HBV DNA levels and solid tumor volume were assessed. Results: At 1 and 2 years, patients receiving the additional Jian-gan granules had significantly lower Child-Pugh scores and higher 2-year survival compared with controls (P 〈 0. 05 ) . There were no statistically significant differences in changes in solid tumor volume or HBV DNA levels between the two groups ( P 〉 0. 05 ) . Conclusion : The Jian-gan granules combined with TACE may improve liver function, survival and quality of life in patients with HCC.
出处
《中西医结合肝病杂志》
CAS
2013年第5期259-261,共3页
Chinese Journal of Integrated Traditional and Western Medicine on Liver Diseases
基金
广西教育厅科研课题(No.201012MS149)
关键词
原发性肝癌
健肝颗粒/治疗应用
经导管动脉栓塞术
临床疗效
hepatocellular carcinoma
Jian-gan granules/therapeutic application, transcatheter arterial chemoembolization
clinical efficacy.