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胶质瘤干细胞耐药相关机制

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摘要 胶质瘤干细胞(glioma stem cell,GSC)具有自我更新和无限增殖的潜能,是引起肿瘤侵袭、增殖、转移、耐药及复发的根源。GSC的高耐药性是恶性胶质瘤化疗效果不佳的重要原因。GSC的多药耐药与ATP结合核转运蛋白、六氧甲基鸟嘌呤DNA甲基转移酶、凋亡抑制蛋白、干细胞巢与血管生成拟态等密切相关,本文对GSC的耐药机制和相关因素进行综述。
出处 《立体定向和功能性神经外科杂志》 2013年第4期246-249,共4页 Chinese Journal of Stereotactic and Functional Neurosurgery
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