摘要
目的：研究高危型人乳头状瘤病毒（high risk human papillomavirus,HR-HPV）感染者负性生活事件暴露与宫颈癌的相关性。方法：对60例感染HR-HPV的宫颈癌患者进行15年回顾性研究,并选取同时期HR-HPV感染且未患宫颈病变者相应病例的年龄、性别、民族和学历配对的人群为对照组。采用Logistic回归分析探讨一般行为因素、饮食及心理因素等对HR-HPV感染的影响。结果：宫颈癌患者血清锌、硒水平分别为（0.719±0.623）和（0.079±0.035）mg/mL,均低于对照组的（1.109±0.121）和（0.208±0.032）mg/mL,差异有统计学意义,t值分别为6.094和8.531,P值分别为0.004和0.002。蛋白质摄入量、蔬果类摄入量高与HR-HPV相关的宫颈癌呈密切负相关,并有明显剂量效应关系。服避孕药、首次性交年龄、多个性伴侣与HR-HPV相关的宫颈癌无关,1~10年有负性生活事件与HRHPV相关的宫颈癌相关。结论：低硒、低锌、长期蛋白质及蔬菜水果摄入量低、1~10年有明显的负性生活事件与高危型HPV感染的致癌性有协同作用。
OBJECTIVE：To study the relationship between negative life events expoure and cervical carcinoma among high risk human papillomavirus（HR-HPV）.METHODS：A 15-year retrospective study was carried out in a cohort of 60 cervical carcinoma with HR-HPV infection,at the same time 1：1matched（age,gender,ethnic,education）60participants of HR-HPV without cervical lesion were selected.Logistic regression analysis was used to explore the associations between behaviors,diet habits psychological factors and HR-HPV.RESULTS：Serum Zn and Se levels were significantly lower in patients with cervical cancer[（0.719±0.623）and（0.079±0.035）mg/mL]than in control subjects[（1.109±0.121）and（0.208±0.032）mg/mL].In the study cases,the mean of selenium and zinc were significantly lower than those of controls（t=6.094,P=0.004;t=8.531,P=0.002）.A close negative correlation was found between the amount of protein and fruit thinning intake with the risk of cervical carcinoma among HR-HPV,and there was dose response relationship.There were no relationships between HR-HPV and using contraceptives,age at first sexual intercourse,multiple sexual partners,but it related to one to ten years psychic trauma.CONCLUSION：There was a synergic intraction between HR-HPV infection and low selenium,low zinc,low protein and fruit thinning intakes in a long term,one to ten years psychic trauma.
出处
《中华肿瘤防治杂志》
CAS
北大核心
2013年第19期1465-1468,共4页
Chinese Journal of Cancer Prevention and Treatment
基金
国家自然科学基金(81160446)
广西科技厅青年科学基金(桂科青099191)
关键词
宫颈肿瘤
人乳头状瘤病毒
负性生活事件
回顾性研究
cervical neoplasms human papillomavirus negative life events retrospective study
