摘要
目的综述血红素氧化酶1(heme oxygenase 1,HO-1)的研究进展,全面了解HO-1的各种作用及其对干细胞成骨、成血管的影响,分析其在骨组织工程中的应用。方法广泛查阅近年来国内外有关HO-1的相关文献,并综合分析。结果 HO-1及其代谢产物不但具有抗炎、抗凋亡和细胞保护作用,而且还可以协调多种因子促进血管生成及对已经存在的血管发挥保护作用。此外,HO-1对干细胞增殖、旁分泌、分化和凋亡有一定影响。结论 HO-1可作为一种多功能的生长因子应用于骨组织工程,但尚需研究各种功能是否具有协同效应,以更好地促进骨修复。
ObjectiveTo review the latest research progress of heme oxygenase 1 （HO-1）, to thoroughly understand different functions of HO-1 and its influence on osteogenesis and angiogenesis of stem cells, and to analyze HO-1 application in bone tissue engineering. MethodsDomestic and international literature on HO-1 in recent years was extensively reviewed and analyzed. ResultsThe activity of HO-1 and its enzymatic products not only have the properties of anti-inflammatory, anti-apoptosis, and cytoprotection, but also can promote angiogenesis combined with other growth factors and protect the vessel which already exist. Moreover, HO-1 has an effect on the proliferation, paracrine signaling, osteoblastic differentiation, and anti-apoptosis of stem cells. ConclusionHO-1 can be used as a multi-function growth factor in bone tissue engineering, but more investigation should emphasis on synergistic effect of each function so as to improve bone repair.
出处
《中国修复重建外科杂志》
CAS
CSCD
北大核心
2013年第10期1256-1261,共6页
Chinese Journal of Reparative and Reconstructive Surgery
