摘要
目的:探讨云南白药致不良反应/不良事件(ADR/ADE)的特点及机制,为临床合理用药提供参考。方法:通过检索国内主要医学数据库,收集38例云南白药致ADR/ADE的原始病例报告,对患者基本信息和ADR/ADE相关情况进行统计分析。结果:云南白药致ADR/ADE的患者中有的存在青霉素、磺胺类药物和云南白药过敏史;云南白药致ADR/ADE以过敏反应(过敏性休克和皮疹)最多,其次为中毒反应;经停药或对症处理患者均恢复正常。结论:云南白药致ADR/ADE的机制主要包括用药剂量过大时某些成分引起的毒性反应及机体与处方成分之间的抗原-抗体反应等。正确选择用药人群,严格按照说明书用药,加强用药指导与用药监测,对于避免和减少云南白药致ADR/ADE有积极意义。
OBJECTIVE： To explore the characteristics of ADR/Ade induced by Yunnan baiyao, anf to provide reference for ra- tional drug use in the clinic. METHODS： Retrieved from main domestic medicine database, 38 cases of ADR/ADE induced by Yan- nan baiyao were collected, and the general information of patients and the ADR/ADE were analyzed statistically. RESULTS： The patients with ADR/ADE induced by Yunnan baiyao had allergic history of penicillin, sulfa-drugs and Yunnai baiyao. The most ADR/ ADE induced by Yutman baiyao were allergic reactions （anaphylactic shock and rash）, followed by toxic reactions. The patients were all recovered after drug withdrawal and symptomatic treatment. CONCLUSIONS： The mechanism of ADR/ADE induced by Yunnan baiyao is that some components results in toxic reaction and antigen-antibody reaction of prescription components, etc. due to over-dose of Yunnan baiyao. It is important to avoid the ADR/ADE induced by Yunnan baiyao that correct choice of patients, medication in accordance with the instructions closely, medication guidance and monitoring.
出处
《中国药房》
CAS
CSCD
2013年第40期3817-3819,共3页
China Pharmacy
