摘要
目的 :观察外周血淋巴细胞rDNA转录活性在人体疾病过程中的动态变化 ,探讨其对肿瘤诊断和治疗监测的意义。方法 :用图像分析系统分析 10 4例癌瘤、心肌梗死、心肌炎患者的外周血淋巴细胞AgNor银染强度 (用以表示rDNA转录活性 )。结果 :癌瘤、心肌梗死、心肌炎患者rDNA转录活性明显降低。癌瘤患者手术后比手术前rDNA转录活性明显降低 ,rDNA转录活性与癌组织DNA >5倍体值呈负相关。结论 :淋巴细胞rDNA转录活性是人体免疫反应的灵敏标志 ,具有广泛的临床应用价值。可作为肿瘤诊断和治疗监测的参考指标 ,但缺乏特异性。
Objective:To explore the dynamic change of rDNA transcription activity of peripheral blood lymphocyte (PBL) in the diseases and its clinical significance Methods: rDNA transcription activity was detected by a cell image analysis of Agnor in 104 cases of patients Results: rDNA transcription activity of PBL was decreased in patients with cancer (except breast cancer) and myocardial infarction, myocarditis, showing a statistically significant difference rDNA transcription activity after operation was significantly decreased than it before operation rDNA transcription activity of patients with cancers and tissues of cancer which DNA>5c showed negative correlation Conclusion: The analysis of rDNA transcription activity is a sensitive marker of immunoreaction in human body Though it can serve as a reference of tumor diagnose and treatment, it has no enough specificity
出处
《中国免疫学杂志》
CAS
CSCD
北大核心
2000年第10期549-550,共2页
Chinese Journal of Immunology
