摘要
目的 :制备盐酸尼卡地平透皮贴剂 ,研究其释药影响因素。方法 :利用Franz扩散池 ,进行离体皮肤体外渗透实验 ,通过改变皮肤的状态 ,研究其体外透皮释药。结果 :盐酸尼卡地平贴剂中药物的渗透可用Higuchi方程来表达。去除角质层皮肤的药物渗透远大于完整皮肤 ,而完整皮肤的贮库效应大于去角质层皮肤。结论 :盐酸尼卡地平在经皮渗透过程中存在贮库效应 ,渗透的主要屏障为角质层。
OBJECTIVE:To prepare nicardipine hydrochloride transdermal therapeutic system and study penetration mechanism. METHODS:Nicardipine permeation tests in vitro through rat skin in franz diffusion cells were performed to study the penetration mechanism of nicardipine by changing rat skin condition. RESULTS:The penetration rate of drug from hydrogel formulations could be described by Higichi's equation. The nicardipine permeation coefficient of stripped stratum corneum skin was higher than that of whole skin, and the deposit function of whole skin was more effecting than that of stripped stratum corneum skin. CONCLUSIONS:The barrier of nicardipine penetration is in the stratum corneum, and nicardipime permeating has the deposit function also in the stratum corneum. [
出处
《中国医院药学杂志》
CAS
CSCD
北大核心
2000年第11期649-651,共3页
Chinese Journal of Hospital Pharmacy
关键词
盐酸尼卡地平
透皮贴剂
贮库效应
体外透皮释药
nicardipine hydrochloride
transdermal therapeutic system
deposit functioT
