摘要
目的分析青年人肺癌患者的临床及病理特征。方法收集2002—10—2012—10收治的116例经病理确诊的青年人肺癌患者的资料，并与同期收治的760例〉45岁的肺癌患者进行对比。结果116例青年人肺癌患者年龄分布为20～44岁，男女比例为15：1。青年组与中老年组早期临床症状均为咳嗽、痰中带血、胸闷，两组比较均无统计学差异（均P〉0．05）。青年组以肺外表现为首发症状和无任何症状的患者均多于中老年组（17．2％vs10．1％，13．8％vs5．4％，均P〈0．01）。青年人肺癌中腺癌居首位，其次为小细胞癌，均明显高于中老年组（60．3％vs28．2％，19．0％vs10．1％，均P〈0．01）。青年组晚期（Ⅲ～Ⅳ期）患者比例明显高于中老年组（78．4％vs47．2％，P〈0．01）。青年组患者选择手术、化疗或者联合治疗的多于中老年组（P〈0．01）。结论青年人肺癌病理类型主要以腺癌和小细胞癌为主，晚期病例多，治疗上更积极。但预后较差。重视青年人肺癌患者的早期表现，及时行相应检查，有助于早期诊断和治疗。
Objective To analyze the clinicopathologic characteristics of young patients with lung cancer. Methods One hundred and sixteen patients aged 20-44 with primary lung cancer （young group） admitted at Zhejiang Provincial People＇s Hospital from 2002 to 2012 and 760 tung cancer patients aged ≥45 （older group） admitted at same period were enrolled in the study. The clinicopathological data were retrospectively analyzed and compared between two groups. Results There were no significant differences in main clinical symptoms （cough, hemoptysis and chest distress） between two groups. However, the rates of asymptomatic patients or with non-respiratory symptoms at admission in young group were higher than those in older group （17.2% vs 10.1%, 13.8% vs 5.4%, both P〈0.01）. The rates of adenocarcinoma and small cell lung cancer in young group were significantly higher than those in older group （60.3% vs 28.2%, 19.0% vs 10.1%, P〈0.01）. Higher percentage of advanced stage in young group than in old group was observed （78.4% vs 47.2%, P〈0.01）. Surgery, chemotherapy or combined modality of treatment were more often applied to young patients than to older ones. Conclusion More adenocarcinoma and small cell lung cancer with advanced stage, aggressive treatment and worse prognosis are observed among young patients with lung cancer than in older patients.
出处
《浙江医学》
CAS
2013年第17期1590-1592,1598,共4页
Zhejiang Medical Journal
关键词
肺癌
青年患者
临床特点
病理类型
Lung cancer Young patients Clinical features Pathological type
