摘要
目的评估2010年上海市松江区含麻疹成分疫苗(MCV)强化免疫的免疫学效果。方法采用多阶段分层随机抽样的方法,在接种1次、2次和3次及以上MCV的儿童中各抽取60人,于强化免疫前和强化免疫后1个月各采集手指末梢血0.5mL,采用ELISA定量检测麻疹病毒血清特异性IgG。结果未发现强化免疫前后的麻疹抗体阳性率存在显著性差异,而强化免疫后的麻疹保护性抗体阳性率和抗体浓度值均比强化免疫前有所上升(P<0.01)。学龄前儿童的免疫前麻疹保护性抗体阳性率和免疫前、免疫后的麻疹抗体浓度值均高于学龄期儿童(P<0.01)。MCV接种3次及以上者,其强化免疫前保护性抗体阳性率和抗体浓度值均低于接种1次或2次者(P<0.01),强化免疫后未发现显著性差异。强化免疫前完成麻疹疫苗免疫程序者,其免疫前麻疹保护性抗体阳性率和免疫前、免疫后的麻疹抗体浓度值均高于未完成者(P<0.01)。结论 MCV强化免疫能有效地提高麻疹保护性抗体阳性率和抗体浓度值。
Objective To evaluate the immunological effectiveness of the supplementary immunization activities of mea- sles-containing vaccine （MCV） in Songjiang district of Shanghai in 2010. Methods 60 children with t dose, 2 doses, or I〉3 doses of MCV respectively were selected randomly, and the blood samples were collected from these children to test the measles IgG antibodies both before and one month after the supplementary immunization （SI）, using enzyme-linked immu- nosorbent assay （ELISA）. Results The positive rate of measles antibody before SI was not significantly different from that one month after SI （P = 0.250）. However, both the positive rate of protection antibody （P 〈 0.01 ） and the average concen- tration of antibody （ P 〈 0.01 ） one month after SI were higher than those before the SI. Preschool children had higher positive rate of protection antibody （ P 〈 0.01 ） than school children before SI, and their average concentration of antibody was higher than that of the school children both before （P 〈 0.01） and after（ P 〈0.01 ） SI. As for children with I〉 3 doses of MCV, the positive rate of protection antibody （P 〈 0.01 ） and the average concentration of antibody （P 〈 0.01 ） were both significantly lower than those with ] or 2 doses before SI but not afer SI （ P 〉 0.05 ）. Comparing children who finished the measles immuni- zation program to those who did not, the former had higher positive rate of protection antibody （P 〈 0.01） before SI and higher average concentration of antibody both before and after （P 〈 O. 01 ） SI. Conclusion The supplementary immunization of MCV can improve the positive rate of protection antibody and the average concentration of the measles antibodies effectively.
出处
《细胞与分子免疫学杂志》
CAS
CSCD
北大核心
2013年第11期1185-1188,共4页
Chinese Journal of Cellular and Molecular Immunology
关键词
麻疹疫苗
强化免疫
阳性率
保护性抗体阳性率
抗体浓度
measles vaccine
supplementary immunization
positive rate
positive rate of protection antibody
concentra-tion of antibody
