摘要
血小板微粒是血小板在激活或凋亡过程中释放的超微膜性囊泡。它不仅是重要的促血栓和促炎症物质,还作为多种生物活性物质的载体介导生物信息在细胞间传递。血小板微粒参与凝血、免疫炎症及血管功能等方面的调控,在动脉粥样硬化的发生、发展过程中发挥重要的作用,有可能成为心血管疾病新的生物标志和治疗靶点。本文主要针对血小板微粒的生物学特性及其在心血管疾病中的作用进行综述。
Platelet-derived microparticle （PMP） is small plasma membrane vesicles shed from platelets upon their activation or apoptosis. Not only PMP is the important prothrombotic and proinflammatory substance, but also its function is used as vehicle for many kinds of bioactive substances mediating intracellular transfer of biological information. PMP is in- volved in regulation of coagulation, immune inflammation and vascular function, playing key roles in the occurrence and de- velopment of atherosclerosis and possibly becoming a new bio-marker and therapeutic target of cardiovascular diseases. This review will mainly focus on biological characteristics of PMP and its roles in cardiovascular diseases.
出处
《中国动脉硬化杂志》
CAS
CSCD
北大核心
2013年第9期849-854,共6页
Chinese Journal of Arteriosclerosis
基金
国家自然科学基金(81270362)资助
关键词
血小板微粒
动脉粥样硬化
心血管疾病
Platelet-derived Microparticle
Atherosclerosis
Cardiovascular Disease
