摘要
毒理基因组学是利用DNA微阵列技术,研究化合物作用于机体后的基因变化,将组学技术与传统毒理学及组织病理学相结合,评价和预测化合物的毒性的一门学科。随着毒理基因组学的广泛应用,免疫毒理学领域也开始利用基因表达谱来分析化合物的免疫毒性。目前认为免疫毒理基因组学可能在下述3个方面具有较高的应用价值,即免疫毒性物质的筛选、免疫毒性作用机制的研究以及免疫毒性风险评估。现围绕这3个方面,对毒理基因组学在免疫毒理学领域中的应用进行阐述。
Toxicogenomics is the subject that researches on the genetic changes by using DNA microarray technology after the compounds acting on the body.It combines omics technologies with conventional toxicology and histopathology in order to evaluate and predict the toxicity of a compound.With the wide application of toxicogenomics,it begins to analyze the immunotoxicity of compounds by using gene expression profiling in immunotoxicity.Currently,scientists believe that the immunotoxicogenomics may have higher value in the following three areas,immunotoxicity screening substances,immune mechanisms of toxicity,and immunotoxicity risk assessment.Therefore,it was discussed in these three aspects of application of immune toxicology in this paper.
出处
《药物评价研究》
CAS
2013年第5期321-326,共6页
Drug Evaluation Research
基金
国家"重大新药创新"科技重大专项-药物安全评价技术平台(2012ZX09302001)
