摘要
目的:研究双参通冠方对急性心肌梗死模型大鼠血流动力学的影响。方法:SD大鼠分为假手术组、模型组及双参通冠低(2.5 g/kg)、中(5 g/kg)、高(7.5 g/kg)剂量组,结扎冠状动脉左前降支建立大鼠心肌梗死模型,于十二指肠给药后0、15、30、60、90、120、180 min,采用PowerLab血流动力学信号采集与分析系统,分别检测大鼠的HR、MAP、LVSP、LVEDP、LVdp/dt max、LVdp/dt min。结果:与假手术组比较,模型组各时间点HR、MAP均升高,LVSP、LVEDP、LVdp/dt max、LVdp/dt min降低(P<0.05)。与模型组比较双参组用药15 min后HR、MAP均降低,LVSP、LVEDP、LVdp/dt max、LVdp/dt min均显著升高(P<0.05)。双参通冠高剂量组LVSP、LVEDP、LVdp/dt max、LVdp/dt min改变与中低剂量组有显著差异(P<0.05)。结论:双参通冠方能增加急性心梗模型大鼠心脏搏出量、降低心肌耗氧量和血管外周阻力,从而改善心功能。
Objective：To research the effects of Shuang Shen Tong Guan Decoction（SSTGD） on hemodynamics in rats with acute myocardial infarction（AMI）. Methods：SD rats were divided into sham operation group, model group, SSTGD low-dose group （2. 5 g/ kg） ,SSTGD middle-dose group （5 g/kg） and SSTGD high-dose group （7. 5 g/kg）. The levels of HR, MAP, LVSP, LVEDP, LVdp/ dtmax and LVdp/dtml. were detected by PowerLab at 0, 15,30,60,90,120,180 min after administration. Results：Compared with the sham operated group, the levels of HR, MAP were increased, the levels of LVSP, LVEDP, LVdp/dtmax and LVdp/dtmin were reduced at each detected point in model group, the difference was significant （ P 〈 0. 05 ）. Compared with the model group, HR and MAP were decreased in SSTGD low-dose group, SSTGD middle-dose group and SSTGD high-dose group after 15 min;LVSP, LVEDP, LVdp/dtm= and LVdp/dtmin were higher,there was significantly difference（P 〈 0.05 ）. Compared with SSTGD low-dose group and SSTGD middle- dose group, the difference of LVSP, LVEDP, LVdp/dtmax and LVdp/dtmin was statistically significant in SSTGD high-dose group （ P 〈 0. 05 ）. Conclusiou：SSTGD can improve cardiac function by increasing heart stroke volume, decreasing cardiac oxygen consumption and total peripheral vascular resistance.
出处
《中药材》
CAS
CSCD
北大核心
2013年第7期1117-1120,共4页
Journal of Chinese Medicinal Materials
基金
国家自然科学基金(30901895
30973830)
国家中医临床研究基地业务建设科研专项(JQZX2012144)
陕西省社会发展攻关项目(2010K17-01)
陕西省教育厅科学研究计划(2013JK0814)
陕西省第五批重点专科心脑血管病科建设项目
国家中医药管理局重点专科心血管病科建设项目
关键词
双参通冠方
心肌梗死模型
血流动力学
Shuang Shen Tong Guan Decoction
Myocardial Infarction model
Blood flow dynamics
