摘要
目的:建立稳定可靠的Korsch XP1压缩参数采集方法,用于研究药物粉体的压缩过程。方法:选择微晶纤维素、乳糖、甘露醇和复合纤维素等直压辅料进行压片,对影响Heckle曲线的平均片重和单片片重、记录片数和记录单元数进行考察。建立方法后选择Prolosv Easytab(塑性)、StaCap1500(弹性)和KCl(脆性)3种不同形变的物质进行验证。结果:合理的数据采集方法能够显著降低压缩参数的变异系数。结论:实验建立的方法可用于Korsch XP1研究药物粉体可压缩性的参数采集。
Objective ： To present an approach that describes a logical gain of compaction parameters＇ data for studying compressibility of pharmaceutical powders using Korseh XP1. Methods： Some directly compressible excipients such as mieroerystalline cellulose, lactose, mannitol and co-processed cellulose were compressed. An effect of average mass of tablets or single tablet on Heckle plot, revolutions and recording times were investigated. Three materials involving Prolosv Easytab （plasiticity）, StaCaplS00 （elasticity） and KC1 （fragmentary） were then used to validate the established method. Results： This approach to collect data significantly decreased the CV （variable coefficient） of compaction parameters. Conclusion： This method is able to be applied to acquire compac- tion parameters.
出处
《中国新药杂志》
CAS
CSCD
北大核心
2013年第19期2301-2308,共8页
Chinese Journal of New Drugs
基金
上海市自然科学基金(10ZR1439200)
上海市教委重点学科项目(J50302)
