摘要
目的探讨p21与Survivin在胃癌发生、发展中的作用及其相关性。方法应用SP免疫组化法分别检测50例胃癌、40例正常胃黏膜组织中p21与Survivin蛋白的阳性表达情况。结果 p21表达阳性率在胃癌与正常对照组中分别为46.0%和77.5%(P<0.05),Survivin表达阳性率在胃癌与正常对照组中分别为56.0%和0%(P<0.05)。p21蛋白阳性表达在分化程度越低、分期越高和淋巴结转移的胃癌组织中显著降低(P<0.05);Survivin的表达在分化程度越低和淋巴结转移的胃癌组织中显著升高(P<0.05)。胃癌组织中p21和Survivin的表达呈负相关(γ=-0.475,P<0.05)。结论 p21和Survivin的异常表达可能与胃癌的发生、发展和浸润转移有关。P21和Survivin可能作为胃癌诊断和预后判断的指标。
Objective To investigate the effect of p21 and Survivin in the occurrence,development of gastric cancer and its correlations. Methods Immunohistochemistry was performed to detect the p21 and Survivin expression in 50 specimens of gastric carcinoma, and 40 specimens of normal mucosa adjacent to carcinoma. Results The positive rates of p21 in gastric carci- noma and normal mueosa were 46.0% and 82.5% , respectively. Meanwhile, the positive rates of Survivin in gastric carcinoma and normal mucosa were 56% and 0% , respectively. There was significant difference （P 〈 0.05 ）. In gastric carcinoma, the p21 expression significantly decreased in stage III or IV tumors, positive lymph-node metastasis, and poorly differentiated adenocarci- noma （ P 〈 0.05 ）. The expression of Survivin significantly increased in positive lymph-node metastasis, and poorly differentiated adenoearcinoma （P 〈 0.05 ）. There was negative correlation between the p21 and Survivin expression in gastric carcinoma （T = -0. 475 ;P 〈 0.05 ）. Conclusion The abnormal expression of p21 and Survivin may be related to the occurrence, development and metastasis of gastric cancer, p21 and Survivin may be used as diagnostic and prognostic markers of gastric cancer.
出处
《实用癌症杂志》
2013年第5期483-485,共3页
The Practical Journal of Cancer
