摘要
目的探讨血清抗子宫内膜抗体(EMAb)联合血清糖类抗原125(CA125)预测早期妊娠先兆流产结局的价值。方法将早孕先兆流产50例病例根据妊娠结局分为两组,即继续妊娠组和妊娠失败组。再选取30例正常早期妊娠妇女为对照组。各组无年龄、孕产次及体质量差异,分别检测3组血清中EMAb,CA125的量,以评价EMAb及CA125在预测早期妊娠先兆流产预后中的价值。结果检测3组患者血清中EMAb阳性率,继续妊娠组(11.43%),对照组(10.00%),妊娠失败组(40.00%)。继续妊娠组与对照组差异无统计学意义(P>0.05)。妊娠失败组明显高于对照组,差异有统计学意义(P<0.05)。检测3组血清CA125的值,继续妊娠组(28.6±12.1)U/mL与对照组(25.2±13.4)U/mL,差异无统计学意义(P>0.05),妊娠失败组(45.1±20.5)U/mL明显高于对照组(25.2±13.4)U/mL,差异有统计学意义(P<0.05)。结论单次血清CA125检测及EMAb检测均可预测早期妊娠先兆流产结局,而两者联合监测可提高其预测敏感度。
Objective To explore the application value of combined detection of anti--endometrial antibody （EMAb） and carbohydrate antigen 125 （CA125） for prognostic evaluation of threatened abortion among patients with early pregnancy. Methods 50 early pregnant women with threatened abortion were divided into two groups based on the outcome of pregnancy, including continuous pregnancy group and failed pregnancy group. 30 cases of normal early pregnant women were enrolled as control group. There were no significant differences of age, maternal time and in weight between the groups. Serum levels of EMAb and CA125 were detected for each group. Results Positive rates of serum EMAb in continuous pregnancy group, control group and failed pregnancy group were 11. 43%, 10.00% and 40.00%, and there was no significance difference of the positive rate between continuous pregnancy group and control group （P〉0.05）, but positive rate in failed pregnancy group was significantly higher than that in control group （P〈0.05）. Serum levels of continuous group and control group were （28.6± 12.1） and （25.2±13.4） U/mL, with no significant difference between them （P〉0.05）, but that of failed pregnancy group was （45.1± 20. 5） U/mL, higher than control group （P〈0. 05）. Conclusion Both CA125 and EMAb detection could predict early pregnancy outcome of threatened abortion, and combined detection could improve prognostic sensitivity.
出处
《检验医学与临床》
CAS
2013年第17期2222-2223,共2页
Laboratory Medicine and Clinic
