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右旋美托咪啶心血管作用机制研究进展

Advances on the mechanism of dexmedetomidine in cardiovascular system
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摘要 右旋美托咪啶(dexmedetomidine,DEX)是一类能和α2-肾上腺素受体高效结合的新型羟甲基衍生物,可起到镇痛、阻滞交感神经的作用,同时还具有镇静、抗焦虑和催眠作用。由于DEX和α2-肾上腺素受体的高亲和性以及α2-肾上腺素受体遍布于全身的特点,DEX不仅仅具有镇静或麻醉作用。本文主要就DEX对心血管的影响作一综述。 Dexmedetomidine（DEX） is a new methylol derivative with high affinity to α 2-adrenergic receptors. It causes analgesia and sympatholysis, and has sedative, anxiolytic, and hypnotic effects.The use of DEX and its affinity to α 2-adrenergic receptors in the body should not only be limited to sedation and anesthesia, because α 2-adrenergic receptors are scattered throughout the body.This review is dealing with the effects of dexmedetomidine in cardiovascular system.
作者 王准 喻文立
机构地区 天津市第一中心医院麻醉科
出处 《武警后勤学院学报（医学版）》 CAS 2013年第8期746-748,共3页 Journal of Logistics University of PAP（Medical Sciences）
关键词 右旋美托咪啶 肾上腺素受体 心血管 Dexmedetomidine Adrenoceptor Cardiovascular
分类号 R917 [医药卫生—药物分析学]
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武警后勤学院学报（医学版）
2013年 第8期

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