摘要
静脉血栓栓塞症(VTE)是妊娠期间的一种常见疾病,是导致孕产妇死亡的最常见原因。孕妇VTE的发生率约为0.1%,孕产妇死亡的主要原因之一为肺栓塞。对妊娠VTE患者给予抗凝治疗可显著降低病死率并可减少再发VTE。妊娠时VTE的治疗和预防应使用低分子肝素或普通肝素,这两种药物不透过胎盘,因而避免了华法林的致畸风险。虽然在妊娠VTE患者中给予溶栓治疗的经验非常有限,但对大块肺栓塞和血流动力学严重受损的妊娠VTE患者给予溶栓治疗很可能起到挽救生命的作用。
Venous thromboembolism（VTE） is a common cause of morbidity and the common cause of maternal death. The incidence of VTE is estimated at 0. 1%, and pulmonary embolism （PE） is one of the lead-ing causes of maternal death. VTE in pregnancy treated with anticoagulant therapy can significantly reduce mortality and reduce the recurrence. The treatment and prophylaxis of VTE in pregnancy both center on the use of unfractionated heparin or low molecular weight heparin, which do not do not cross the placenta, thus avoiding the risk of teratogenicity of warfarin. Although experience with thrombolytic therapy in pregnancy is limited,these agents may be life saving in patients with massive PE and severe hemodynamic damage.
出处
《医学综述》
2013年第18期3341-3343,共3页
Medical Recapitulate
关键词
静脉血栓栓塞症
妊娠
治疗
Venous thromboembolism
Pregnancy
Therapy
