摘要
sesns是一类高度保守的应激诱导蛋白,可保护细胞免受氧化应激损害。然而,它们的生理及生化作用并不依赖其氧化还原活性。在哺乳动物和果蝇中,sesns可促进腺苷酸活化蛋白激酶(AMPK)的活化。应激可引起sesns表达,从而抑制雷帕霉素靶点复合物1。果蝇的sesns(dSesn)可以看作是雷帕霉素靶点的一种负反馈调节剂。近年来,sesns在应激、癌症、新陈代谢及衰老方面的作用受到越来越多的关注。
Sestrins are a family of highly conserved stress-responsive proteins that can protect cells from oxidative stress. However,their major biochemical and physiological function does not appear to depend on their redox （ reduction and oxidation ） activity. Sestfins promote activation of adenosine-5-monophosphate （AMP）-dependent protein kinase in both mammals and fruit flies. Stress induced sestrins expression results in inhibition of the target of rapamycin complex 1 （ TORC1 ）. Drosophila sestrin（dSesn） appears to be a nega-tive feedback regulator of target of rapamycin（TOR）. Recently, more and more attention are paid to sestrins effect on stress, cancer, metabolism and aging.
出处
《医学综述》
2013年第18期3265-3268,共4页
Medical Recapitulate
基金
国家自然科学基金(81270251/H0205)
