摘要
目的分析基质金属蛋白酶（MMP）-2和MMP-9在食管癌患者血清中的表达与食管癌临床病理因素之间的关系。方法应用酶联免疫吸附法检测60例食管癌患者血清中MMP-2、MMP-9的含量与患者年龄、性别、组织学类型、临床分期及区域淋巴结转移等临床病理因素之间的关系。结果对照组血清中MMP-2和MMP-9的浓度均值分别为61．31、87．67ng／ml，而食管癌患者血清中MMP-2和MMP-9的浓度均值分别121．66、169．73ng／ml，均高于正常者血清中含量，差异有统计学意义（t=3．015，P=0．007；t=2．037，P=0．04）。MMP-2的含量与有无淋巴结转移（t=2．150，P=0．04）及临床分期（t=2．186，P=0．03）有关，MMP-9的含量与有无淋巴结转移（t=2．390，P=0．02）及临床分期（t=2．149，P=0．03）有关。MMP-2和MMP-9的含量均与食管癌患者的年龄、性别、组织学类型无关（均P〉0．05）。结论MMP-2和MMP-9可能与食管癌的侵袭转移有关。
Objective To analyze the expression levels of matrix metallo proteinase-2 （MMP-2） and matrix metallo proteinase-9 （MMP-9） in sertun of patients with esophageal cancer, and to analyze the interrelations among MMP-2, MMP-9 and clinicopathologic characteristics of esophageal cancer. Methods The levels of serum MMP-2, MMP-9 from 60 patients with esophageal cancer were detected by enzyme linked immunosorbent assay. The interrela- tions among MMP-2, MMP-9 and clinicopathologic characteristics of esophageal cancer including age, gender, histo- logical type, whether or not lymph nodes metastasis and TNM staging were analyzed. Results The levels of MMP-2 and MMP-9 in control group were 61.31 ng/ml and 87.67 ng/ml, the levels of MMP-2 and MMP-9 in patients with esophageal cancer were 121.66 ng/ml and 169.73 ng/ml. The levels of MMP-2 and MMP-9 were significantly higher in patients with esophageal cancer than that of general population （t = 3.015, P = 0. 007 ; t = 2.037, P = 0. 04）. The level of MMP-2 was significantly associated with whether or not lymph node metastasis （t = 2. 150, P = 0. 04） and clinical staging （t =2. 186, P=0.03）. The level of MMP-9 was significantly associated with whether or not lymph node metastasis （t = 2. 390, P = 0.02） and clinical staging （t = 2. 149, P = 0. 03）. The levels of MMP-2 and MMP-9 have no reference to age, gender and histological type （all P 〉 0. 05）. Conclusion MMP-2 and MMP-9 may corre- late with tumor invasion and metastasis in patients with esophageal cancer.
出处
《国际肿瘤学杂志》
CAS
2013年第9期708-711,共4页
Journal of International Oncology
关键词
食管肿瘤
基质金属蛋白酶2
基质金属蛋白酶9
Esophageal neoplasms
Matrix metalloproteinase 2
Matrix metalloproteinase 9
