摘要
目的观察消癖系列口服液对乳腺癌前病变大鼠血管生成的影响,探讨其阻断或逆转乳腺癌前病变发展的可能机制。方法 1,7,12-二甲基苯并蒽(DMBA)联合雌孕激素序贯法复制大鼠乳腺癌前病变模型,观察消癖口服液组、他莫昔芬组和模型组大鼠乳腺组织微血管密度(microvessel density,MVD)及血管内皮生长因子(vascular endothelial growth factor,VEGF)表达。结果消癖口服液可降低乳腺癌前病变大鼠的乳腺癌发生率,显著降低大鼠乳腺癌前病变组织的MVD值,但对VEGF无明显抑制作用。结论消癖系列口服液能抑制大鼠乳腺癌前病变组织内血管的生成,从而阻断大鼠乳腺癌前病变的发展,但这并不是通过抑制VEGF通路实现的。
Objective To investigate the effect of Xiaopi oral solution on angiogenesis in breast precancerous lesion rats, and to explore its possible reversing mechanism for breast precancerous lesion. Methods The rat model of breast precancerous lesion was established by 1, 7, 12-dimethyl-benzanthraeene （DMBA） combined with estrogen and progesterone sequential method. After modeling and treatment, we compared mierovessel density （MVD） and the expression of vascular endothelial growth factor（VECF） in the mammary gland of Xiaopi oral liquid group, tamoxifen group and the model group. Results Xiaopi oral liquid could reduce the incidence of breast cancer in breast precancerous lesion rats, significantly lower MVD, but had no inhibitory effect on the expression level of VEGF in the mammary gland of breast precancerous lesion rats. Conclusion Xiaopi oral liquid can inhibit the angiogenesis in precancerous lesion rats, thus to block the development of breast cancer, but its mechanism is not through the inhibition of the VEGF pathway.
出处
《中药新药与临床药理》
CAS
CSCD
北大核心
2013年第5期451-454,共4页
Traditional Chinese Drug Research and Clinical Pharmacology
关键词
消癖系列口服液
微血管密度
血管内皮生长因子
乳腺癌前病变
Xiaopi oral solution
Mierovessel density
Vascular endothelial growth factor
Breast precancerous lesions
