摘要
目的探讨2型糖尿病病人血清白细胞介素-10(IL-10)、白细胞介素-18(IL-18)与糖尿病性视网膜病变(DR)的相关性。方法检测40例单纯2型糖尿病病人(DM组)及40例伴有DR的2型糖尿病病人(DM+DR组)血清IL-10和IL-18水平,以无2型糖尿病及DR的40例正常人作为正常对照组。结果 DM组、DM+DR组IL-18明显高于正常对照组,DM+DR组IL-18高于DM组,差异均有显著性(F=6.34,P<0.05)。DM+DR组、DM组IL-10低于正常对照组,差异有显著性(F=6.45,P<0.05);DM+DR组、DM组IL-10比较,差异无显著性(P>0.05)。结论 DR的发生与血清IL-18水平的变化有一定关系。
Objective To investigate the relationship between serum interlrukiml0 （IL-10）, interlrukin-18 （IL 18） and diabetic retinopathy （DR）. Methods The serum levels of IL-10 and II. 18 were detected in 40 patients with type 2 diabetes （DM） and 40 patients with DM accompanying DR （DM＋DR）, and 40 healthy adults served as controls. Results The levels of IL-18 in DM and DM＋DR groups were higher than that in the control, that in the DM＋DR were higher than that in the DM, the differences being significant （F=6.B4,P〈0.05）. The levels of IL-10 in the DM＋DR and DM were lower than that in the normal control （F=6.45 ,P〈0.05）. The difference of IL-10 levels between the DM＋DR and DM groups was not significant （P〉0.05）. Conclusion The occurrence of DR is associated with the changes of serum level of IL-18.
出处
《青岛大学医学院学报》
CAS
2013年第6期524-525,527,共3页
Acta Academiae Medicinae Qingdao Universitatis
