摘要
背景缺血半暗带的发现使脑梗死后溶栓治疗的必要性得到了理论上的支持,然而随着灌注的恢复,在缺血半暗带内受损脑组织逐步恢复其正常功能的过程中,存在着一系列复杂的机制。目的探讨缺血半暗带发展的过程,为挽救缺血半暗带内存活的细胞提出新的思路。内容主要综述缺血半暗带内损伤性机制与保护性机制之间的关系。趋向脑梗死后,在最大限度地发挥内源性保护机制的基础上挽救受损伤的脑组织将变得尤为重要。
Background The discovery of ischemic penumbra provides theoretical support for the necessity of thrombolytic therapy after cerebral infarction. However, with the restoration of perfusion, a series of complex mechanisms exist in the process that the injured brain tissues in ischemie penumbra gradually resume their normal function. Objective To explore the developmental process of ischemic penumbra,and to put forward the new ideas of saving the survived cells in ischemic penumbra. Content This article reviews the relationship between the damaging mechanisms and the protective mechanisms in ischemic penumbra after cerebral infarction. Trend It will become particularly important to save the injured brain tissue on the basis of maximizing the endogenous protective mechanism after cerebral infarction.
出处
《国际麻醉学与复苏杂志》
CAS
2013年第10期953-958,共6页
International Journal of Anesthesiology and Resuscitation
关键词
脑梗死
缺血半暗带
Cerebral infarction
Ischemic penumbra