摘要
背景组织酸化是炎症、缺血／缺氧、骨质破坏等多种疼痛条件下的共同病理特征。酸敏感离子通道（acid-sensing ion channels，ASICs）是一类兴奋性阳离子通道，表达在神经系统，可直接被细胞外质子激活，介导组织酸化所致的伤害性感受。目的以ASICs为疼痛治疗靶标，将为疼痛治疗提供一条新途径。内容综述ASICs参与组织酸化所致伤害性感受的相关研究。趋向近年来，研究发现ASICs在介导组织酸化所致伤害性感受过程中发挥重要作用，以ASICs为靶点，将为开发新型镇痛药物和疼痛治疗提供新思路。
Background Tissue acidosis is a common pathological feature of many painful conditions including inflammation, ischemia and bone destruction. Acid sensing ion channels （ASICs） are excitatory cation channels directly activated by extracellular protons that are expressed in the nervous system, and mediate nociception indcued by tissue acidosis. Objective It will provide a new approach to take ASICs for pain treatment targets. Content The studies of ASICs in mediating nociception associated with tissue acidosis is reviewed. Trend Recent studies show that ASICs play a key role in mediating nociception associated with tissue acidosis, and it will provide a novel approach for development new analgesic drugs and pain treatment targeted ASICs.
出处
《国际麻醉学与复苏杂志》
CAS
2013年第10期949-952,共4页
International Journal of Anesthesiology and Resuscitation
基金
国家自然科学基金项目（81070888,81230025,81300975,81371243.81100813）
