摘要
目的比较地佐辛与帕瑞昔布钠用于维吾尔族妇科患者经腹手术的术后镇痛中的效果。方法40例在全麻下行择期妇科经腹手术的维吾尔族女性患者，年龄25岁～55岁，美国麻醉医师协会（ASA）分级Ⅰ或Ⅱ级，按随机数字表法均分为两组（每组20例）：地佐辛组（A组）和帕瑞昔布钠组（B组），手术结束前30rain分别给予地佐辛0．1mg／kg（A组）、帕瑞昔布钠40mg（B组）。分别记录两组患者拔管后的苏醒时间、Ramsay镇静评分、舒适度评分（brugg-rmann comfort scale，BCSo采用双盲法进行术后视觉模拟（visual analogue scale／score，VAS）评分、芬太尼的追加剂量以及副作用。结果A组VAS评分在拔管后（2．4±2．2）及术后12h（3．2±2．4）明显低于B组[（3．9±2．0）、（4．3±2．1）]（P〈0．05），BCS评分A组（2．0±0．4）高于B组（1．4±0．9）（P〈0．05），A组苏醒期芬太尼追加量[（21±42）μg]明显低于B组[（47±40）μg]（P〈0．05）。结论采用地佐辛0．1mg／kg静脉注射的镇痛效果在维吾尔族妇科手术中优于帕瑞昔布钠40mg，适用于创伤较大的中、大型手术。
Objective To compare the effect of multi-modal analgesia between dezocine and parecoxib sodium in Uighur patients undergoing gynecological laparotomy. Methods 40 Uighur patients scheduled for elective gynecological laparotomy under general anesthesia, aged 25-55 years old, ASA Ⅰ -Ⅱ , were randomly divided into two groups, dezocine group （group A） and parecoxib sodium group （group B ）. Dezoeine 0.1 mg/kg and parecoxib sodium 40 mg were administered 30 min before the end of surgery respectively. The awakening time, Ramsay sedation score and brugg-rmann comfort scale （BCS） were recorded in both groups. Visual analogue scale （VAS）, rescue dose of fentanyl and its side effects were recorded using double blind method. Results The VAS of group A after extubation （2.4±2.2） and 24 h postoperative （3.2±2.4） were less than that of group B [ （3.9± 2.0）, （4.3±2.1）] （P〈0.05）, while the BCS of group A （2.0±0.4） was higher than that in group B （1.4±0.9）, with statistically significant difference （P〈0.05）. The rescue dose of fentanyl in group A [（21±42） μg] was significantly less （P〈0.05） than that in group B [ （47±40） μg] . Conclusions The analgesia effect of dezocine 0.1 mg/kg intravenously is better than that of parecoxib sodium 40 mg for Uighur women undergoing gynecological laparotomy, especially in medium and major operation.
出处
《国际麻醉学与复苏杂志》
CAS
2013年第10期889-891,共3页
International Journal of Anesthesiology and Resuscitation
关键词
地佐辛
帕瑞昔布钠
维吾尔族
术后镇痛
Dezocine
Parecoxib sodium
Uighur
Postoperative analgesia
