摘要
目的:基于数据挖掘方法探索脂肪肝肝郁脾虚证用药规律。方法:利用VIP、CBM和CNKI等数据库检索创建以来至2012年9月关于中治疗脂肪肝肝郁脾虚证的文献,同时手工检索2002～2012年出版的有关脂肪肝肝郁脾虚证论述的书目。将符合要求的文献和书目建立数据库,由研究人员对文献进行筛选和数据提取,进行频数分析、聚类分析,关联规则分析。对主要药物、药对(组)规律进行研究。结果:在治疗脂肪肝肝郁脾虚证的104首中药复方中,涉及163种药物,使用频次为1 227次;其中使用频次在4次以上的共46种、共855频次;作为主要药物进行聚类分析,共分为6类:疏肝类、健脾类、化痰类、行气类、化瘀类、消食类;经关联规则分析,共得药对规则14条,药组规则62条,主要为疏肝理气药与健脾祛湿药的配伍组合。结论:数据挖掘能够更好的探索治疗脂肪肝肝郁脾虚证用药规律,更好的指导临床和中药开发。
Objective： To explore medication rule for treating the liver depression and spleen deficiency of fatty liver disease based on data mining. Method： VIP, CBM and CNKI database were used to collect literatures from the foundation of th database to September 2012 and abibliography literature from 2002 to 2012 by hand on traditional Chinese medicine （TCM） treating the liver depression and spleen deficiency of fatty liver disease. The database meeting the requirement was established for data mining using frequency count, clusteranalysis and association rule to analyze regularity of key herbs and a pair （group） of herbs. Result： There were 104 prescriptions （totaling 163 herbs and 1 227 counts of frequency） in the compound herbal fomulae for liver depression and spleen deficiency of fatty liver disease. The herbs which were used for more than 4 times included 46 herbs （totaling 855 counts of frequency）. They were analyzed and classified into 6 clustersincluding tonic, soothing liver drugs, strengthening spleen drugs, apophlegmatisant drugs, regulating Qi agent, absorb clots drugs and promoting digestion. The rules in pair of herbs werel4, and rules in group of herbs were 62 by association analysis. The rules consisted mostly of compatibility of relieving the depressed liver and Spleen-strengthening and Damp-removing. Conclusion： Data mining is able to better explore the medication rule of the liver Depression and Spleen deficiency of fatty liver disease which better able to guide the clinic and TCM development.
出处
《中国实验方剂学杂志》
CAS
北大核心
2013年第19期344-348,共5页
Chinese Journal of Experimental Traditional Medical Formulae
基金
国家自然科学基金面上项目(81273617)
国家中医药管理局科研专项基金项目(102-03JP39)
广东省自然科学基金项目(31876)
广东省科技计划项目(2005B33001011)
中国博士后科学基金项目(12002031295)
关键词
数据挖掘
脂肪肝
肝郁脾虚
用药规律
data mining
fatty liver disease
liver depression and spleen deficiency
medication rule
