摘要
目的:探讨营养支持联合新辅助化疗对胃癌病人疗效、营养状况及机体组成变化的研究。方法:对88例以淋巴结转移为主的进展期胃癌采用卡培他滨+奥沙利铂方案化疗,并采用肠内营养支持,分析研究化疗疗效、手术情况、机体组成变化和化疗毒副反应情况。结果:88例中完全缓解(CR)4例(4.5%),部分缓解(PR)44例(50.0%),稳定(NC)32例(36.3%),进展(PD)8例(9.0%),近期客观有效率(CR+PR)为54.5%。平均体重、体质指数(BMI)和肌肉群(LBM)增加明显,并有统计学意义(P<0.05),其中体重增加>10%者16例,增加>5%者28例,维持不变者20例,下降者24例。行D2根治手术52例(59.1%),D2+根治手术24例(27.2%),姑息切除手术12例(13.6%),手术根治切除率达86.4%。结论:营养支持能改善进展期胃癌行新辅助化疗病人营养状况,提高生活质量,并顺利完成抗肿瘤治疗。
Objective：This study aimed to evaluate the clinical effectiveness of neoadjuvant chemotherapy in the treatment of advanced gastric cancer patients retrospectively. Methods ： 88 patients with advanced gastric cancer received nutritional support combined with chemotherapy： Oxaliplatin 130 mg/m2 i. v, the first day, and oral capecitabine 2 500 mg/m2, from the first day to the fourteenth day, repeated every 3 weeks. Results ：4 cases （4.5%） achieved CR,44 cases （50.0%） had PR, 32 cases （36.3%） had NC, 8 cases（9.0% ） had PD, with an overall response rate of 54.5%. The patients had significant increases in body weight on average, body mass index and lean bodymass on average （P 〈 0.05）. 52 cases underwent D2 radical resection,24 cases underwent D2 ＋ radical resection, 12 cases un- derwent palliative gastrectomy, and the radical resection rate was 86.4%. Conclusion：Enteral nutri- tion support can improve the nutritional status and quality of life of progressive gastric cancer patients during the neoadjuvant chemotherapy and help to accomplish the whole therapeutic protocol safely and effectively.
出处
《肠外与肠内营养》
CAS
北大核心
2013年第5期263-266,共4页
Parenteral & Enteral Nutrition
基金
江苏省社会发展基金资助(BS2007054)
南京军区科技创新基金资助(07Z028)
关键词
营养支持
新辅助化疗
进展期胃癌
机体组成
Nutritional support
Neoadjuvant chemotherapy
Advanced gastric cancer
Body composition
