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国产自攻型微螺钉种植体感染的实验研究 被引量:2

Experimental study on metainfective self-driving micro-screw implant
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摘要 目的:建立感染微种植体动物模型,观察未加力状态下不同时间段,微螺钉种植体-骨界面各部位的组织变化。方法:健康雄性杂种犬4只,在犬的双侧上颌尖牙近远中、第二双尖牙近远中颊侧骨板各植入微螺钉种植体一只,共16只。微螺钉种植体颈部缠绕正畸橡皮圈及4-0缝合线。分别于术后1周、2周、4周、8周处死动物。HE染色法观察不同时间段种植体-骨界面的变化。结果:观察期内种植体出现松动、未脱落,1周时种植体周围牙龈粘膜出现明显的红、肿等炎性反应,光镜下出现大量的急慢性炎症细胞,毛细血管增生扩张,有少许新生纤维组织,越接近尖部炎性反应越轻;2周时中部骨质的连续性破坏;4周见颈部少量的骨质破坏,同时有片状的新生骨形成;8周时颈部骨质破坏吸收。结论:国产自攻型微螺钉种植体在感染状态下,骨质的吸收是由颈部向尖部进行的。 Objective: The aim of this study was, through the metainfective animal experiment, to observe histological alterations of the different part of the tissue surrounding micro-screw implant for different time (one, two, four, eigth weeks) and to disscuss the healing model of jaw after insertion of microscrew. In the end, hope to give some advice to the clinical operation. Methods: Four male crossbred dogs and sixteen micro-screw implant. There were inserted into by the self-driving microscrew in the upper canines vicinity at cuspidal and molar of crossbred dogs respetively, cotton ligatures and rubber were placed around the healing-abutments to make infect. These dogs were sacrificed at one, two, four, eight weeks in excessive anesthesia respectively. The bone-implant samples were made and were observed under optical microscope after HE stained. Results: Mobility of only two microscrew was observed,but not lost. One weekly, the microscopic features of group were chronic inflammatory changes in the crevices of the implants. Varying degrees of fibrous tissues can be seen. Two weekly, Osteoclasts can been seen with the destruetion of bone. Four weekly, bone destruetion can be seen. Eight wekly, connective tissues can be seen in middle of implants. Conclusion: Micro-screw implants in the infection, bone absorption by the neck to the tip of the microscrew implant.
出处 《中国口腔种植学杂志》 2013年第3期122-124,共3页 Chinese Journal of Oral Implantology
关键词 种植体 支抗 感染 组织学 microscrew implant anchorage infect histolog
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