摘要
目的 观察百草枯中毒患者丙二醛（MDA）、转化生子因子β1（TGF-β1）的动态变化.方法 在中毒后第1、3、5、7、14、21、28天通过硫代巴比妥比色法、双抗体夹心法分别检测中毒组及健康对照组MDA、TGF-β1水平,同步行胸部CT检查.结果 与健康对照组相比,中毒组外周血MDA、TGF-β1水平明显升高（P＜0.05或P＜0.01）,但MDA随时间推移及胸部CT肺间质纤维化逐渐加重呈逐渐下降趋势,而TGF-β1呈持续高水平.结论 TGF-β1可能与肺间质纤维化的发生有关.
Objective To observe the dynamic changes of malondialdehyde （MDA）, transforming growth factor-β1 （TGF-β1 ） in patients with paraquat poisoning. Methods The levels of MDA, TGF-β1 of paraquat poisoning group and healthy control group were determined on the 1st, 3 rd, 5 th, 7 th, 14 th, 21 st, 28th days after poisoning by penthiobarbital colorimetric and double antibody sandwich method, and the chest CT was examined synchronously. Results Compared with healthy control group,the levels of MDA and TGF-β1 in peripheral blood of paraquat poisoning group increased （ P 〈0.05 or P 〈0.01）. The level of MDA showed declining trend and the level of TGF-β1 was increased with the time and pulmonary interstitial fibrosis. Conclusions TGF-β1 may play an important role in the development of pulmonary interstitial fibrosis induced by paraquat.
出处
《国际呼吸杂志》
2013年第18期1392-1394,共3页
International Journal of Respiration
基金
陕西省科学技术研究发展计划项目（2012SF2-19）
关键词
百草枯
肺间质纤维化
丙二醛
转化生长因子Β1
Paraquat
Pulmonary interstitial fibrosis
Malondialdehyde
Transforming growthfactor-β1
