摘要
目的：探讨脑膜癌病（Mc）的临床及脑脊液（CSF）特征。方法：回顾性分析27例MC患者的临床表现及CSF细胞学改变。结果：本组患者以中老年多见（25例）；主要临床表现为头痛、恶心呕吐、视乳头水肿、脑膜刺激征、周围神经损害。10例患者颅脑MRI增强扫描表现为颅内转移灶或脑膜异常强化信号。CSF压力偏高15例，细胞数增多22例，多呈中～重度增加，淋巴及单核细胞增加为主。27例患者CSF中均找到异形肿瘤细胞（其中3例多次腰穿后确诊），20例找到原发灶；16例死亡，l例存活，10例失访。结论：MC的临床及影像学表现缺乏特异性，CSF细胞学检查发现异形肿瘤细胞是确诊该病的可靠依据，多次反复腰穿检查可提高诊断准确率。
Objective： To discuss the clinical and cytological features of cerebrospinal fluid （CSF） in patients with meningeal carcinomatosis （MC）. Methods： The clinical data of 27 MC patients were analyzed retrospective- ly. Results： Most patients were middle and elderly aged （25 cases）. The clinical manifestations of 27 patients were characterized by headache, nausea and vomit, meningeal irritation signs and peripheral nerve injury. MR/ enhancement scanning revealed abnormally intracranial metastasis or mater enhancement in 10 cases. Cerebrospinal pressure was increased in 15 cases. Cell population of CSF in moderately to severely increased in 22 cases, in which the activated monoeytes and lymphocytes predominated. Heteromorphic tumor cells in CSF were found in all of 27 cases. Primary tumors were revealed in 20 cases. Conclusion： The clinical features and imaging results of MC are nonspecific. The detection of malignant cells through cytological examination in CSF is a reliable diagnosing method for MC. Repeated CSF cytological examination may be needed for diagnostic accuracy.
出处
《神经损伤与功能重建》
2013年第5期360-363,共4页
Neural Injury and Functional Reconstruction
关键词
脑膜癌病
脑脊液
细胞学检查
meningeal carcinomatosis
cerebrospinal fluid
cytological examination
