摘要
目的：探讨头颈部侵袭性纤维瘤的临床表现、病理特征、治疗方式及预后。方法：根据2005年世界卫生组织的肿瘤类指导原则，回顾性分析2008～2012年间收治9例头颈部侵袭性纤维瘤的临床资料并复习相关文献。结果：发病部位以颈部（3例）、下颌下区（2例）最为常见，其次是上颌骨、颧部、眶下区、腮腺各1例，对9例患者都实施手术切除，4例患者因肿瘤已侵犯头颈部重要结构，无法获得阴性切缘，其中1例患者发生恶变，接受放射治疗，另2例术后未接受综合治疗，术后复发，所有病例无远处转移，随访时间为6～51个月。结论：头颈部侵袭性纤维瘤诊断主要依靠术后病理，彻底手术切除是治疗并减少复发的主要手段，对于复发或难以完整切除的病例可配合放化疗，且术后长时间密切随访。
Objective： To assess the clinic manifestation, pathologic charactor, therapy and prognosis of aggressive fibromatosis in head and neck. Methods： Under the 2005 World Health Organization classification guidelines 9 patients with aggressive fibromatosis were diagnosed and treated from 2008 to 2012 and related literature were reviewed. Results： The lesions were located in the subman- dibular area in 2 patients, in neck in 3, in maxilla in 1, in zygomatic part in 1, in infraorbital area in 1 and in parotid gland in 1 pa- tient respectively. Then, they were all treated by local resection, 1 patient with malignant transformation underwent radiotherapy, 2 pa- tients with reeurence after surgical resection. No metastasis was found in all cases in 6 to 51 month follow-up. Conclusion： Diagnosis of aggressive fibromatosis is depend on pathologic examination. Surgical removal of the tumor is the main treatment. Chemotherapy and radiotherapy may be used for the patients with unresectahle or partially resected tumor when the tumor is adjacent to vital structures. Long term follow up is suggested for the patients.
出处
《实用口腔医学杂志》
CAS
CSCD
北大核心
2013年第5期690-693,共4页
Journal of Practical Stomatology
关键词
头颈部肿瘤
侵袭性纤维瘤
外科手术
放疗
Head and neck neoplasm
Aggressive fibromatosis
Surgical procedures
Radiotherapy
