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动脉粥样硬化斑块消退新进展 被引量:5

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摘要 动脉粥样硬化是一种慢性进展性疾病,血管壁的恶性重构一度被认为不可逆转。但随着对动脉粥样硬化病因发病机制理解的深入,人们逐渐认识到动脉壁病灶内存在的脂质进出及病理细胞的聚散始终是个动态过程。不管是早期的脂纹脂斑,还是中晚期的纤维斑块、粥样斑块以及复合病变,只要给病变提供合适得当的内外环境,就有可能逆转病变进程,改变斑块结构甚至使其完全消退。鉴于消退模型及消退机制的迅猛发展,本文特就此问题进行简要阐述,以便为临床药物的研究和病变消退的治疗策略提供一定的指导。
出处 《中华心血管病杂志》 CAS CSCD 北大核心 2013年第9期808-811,共4页 Chinese Journal of Cardiology
基金 国家自然科学基金(81170279,81370408) 江苏省创新团队基金(LJ201116) 江苏省自然科学基金(BK2011486,BK20131246)
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