摘要
目的探究T-cadherin与宫颈癌的关系。方法 50例宫颈癌组织标本,采用免疫组化、免疫印迹和RT-PCR检测宫颈癌组织中T-cadherin的表达水平,并以40例宫颈上皮内瘤变组织和15例正常宫颈组织作对照。结果宫颈癌组织中T-cadherin蛋白、T-cadherin基因的表达显著低于宫颈上皮内瘤变组织(P<0.05)和正常的宫颈癌组织(P<0.01)。结论 T-cadherin表达下调与宫颈癌发生有关,并可能促进宫颈癌的侵袭与转移。
Objective To investigate the relationship between truncated-cadherin （ T-cadherin ） and cervical cancer.Methods Immunochemistry,Western blot and RT-PCR were adopted to detect the expression of T-cadherin in 50 samples of cervical cancer tissues ,40 samples of cervical intraepithelial neoplasia （ CIN） tissues and 15 samples of normal cervical tissues as the controls .Results Compared to cervical cancer tissues ,the expressions of T-cadherin pro-tein and mRNA in the cervical cancer tissues were significantly lower than those in the CIN tissues （P〈0.05） or normal cervical tissues （P〈0.01）.Conclusion The down-regulation of T-cadherin expression correlates with cervical canc-er,which may promote the invasion and metastasis of cervical cancer .
出处
《广西医学》
CAS
2013年第10期1280-1283,共4页
Guangxi Medical Journal
基金
陕西省科技攻关项目(2011k13-01-13)
