摘要
Alzheimer病（Alzheimer＇s disease,AD）是一种进行性神经变性疾病,它是导致老年痴呆的主要原因且至今无法治愈.β淀粉样蛋白斑块沉积和tau蛋白引起的神经纤维缠结是导致AD患者大脑病变的两大主要机制.近来发现越来越多的AD患者除了意识和行为障碍,还存在眼部症状.有研究表明AD相关的β淀粉样蛋白斑块不仅沉积于大脑,同时累及视网膜,且视网膜病变较大脑病变更易观察诊断.因此,研究AD相关的视网膜变性不仅有助于深入了解脑部病变过程,为AD提供一种全新的简单有效的诊疗方法,也有益于研究如青光眼和年龄相关性黄斑变性等其他视网膜变性类疾病的病理机制.
Alzheimer＇s disease （AD）,a devastating neurodegenerative disease,is the primary cause of dementia with no cure available.Amyloid plaques and neurofibrillary tangles underlie the two pathological hallmarks in AD brain.In addition to cognitive and behavioral deficits,vision abnormalities are prevalent in AD patients.While most AD related pathology occurs in the brain,the disease has also been reported to affect the retina,which is more accessible for imaging than the brain.Therefore,studying AD-related retinal degeneration is a promising way for the investigation on AD pathologies and therapies that would eventually benefit the brain and cellular mechanisms in other retinal degenerations such as glaucoma and age-related macular degeneration.
出处
《国际眼科纵览》
2013年第4期260-264,共5页
International Review of Ophthalmology
