摘要
目的探讨吸人沙美特罗替卡松气雾剂治疗4—5岁学龄前哮喘患儿的临床疗效。方法在哮喘门诊和呼吸科病房收集学龄前哮喘儿童74例，分为沙美特罗替卡松组（n=37）和丙酸氟替卡松组（n=37），分别进行吸人治疗，症状量化评分，并定期随访，观察比较两组1周、1个月、3个月的临床疗效。结果两组间日间评分、夜间评分在基线期、第1周、第1个月差异无统计学意义（P〉0．05），在第3个月时沙美特罗替卡松组日间评分（0．16±0．09VS0．32±0．11，P〈0．05）及夜间评分（0．04±0．01VS0．14±0．00，P〈0．05）均低于丙酸氟替卡组。沙美特罗替卡松组顺利进行降级治疗的患儿人数高于丙酸氟替卡松组（x2=4．57，P〈0．05）。结论哮喘急性期吸入沙美特罗替卡松气雾剂及丙酸氟替卡松气雾剂后均能较快得到缓解，其效果相似。吸人沙美特罗替卡松气雾剂较吸人丙酸氟替卡松气雾剂对于哮喘缓解期症状的控制效果可能更佳。
Objective To study the effect of inhalation combined salmeterol plus fluticasone propionate in treatment of asthma in children between 4 ~ 5 years old. Methods Seventy-four children （ age range,4 ~ 5 years） were enrolled for our study, they were randomly divided into 2 groups （ one group inhaled combined sal- meterol plus fluticasone, 37 children; the other group inhaled fhiticasone, 37 children）. Comparative studies of clinical efficacy, quantified symptom score, and regular follow-up observations were conducted at the interval of one week, one month, three months. Results In the first week and first month during the treatment, there were no difference between salmeterol plus fluticasone group and fluticasone group （ P 〉 0. 05 ）. In the third month during the treatment,the daytime ratings（0. 16 ±0. 09 vs 0. 32 ±0. 11 ,P 〈0. 05） and night ratings（0. 04 ±0. 01 vs 0. 14 ± 0. 00 ,P 〈 0. 05 ） of salmeterol plus fluticasone group were significantly better than those of fluticasone group. After three months, more children in salmeterol plus fluticasone group were responsive to the decreased dose of the drug than those of fluticasone group （x2 = 4. 57,P 〈 0. 05 ）. Conclusion In the follow-up of exac- erbations, treatment with combined salmeterol and fluticasone propionate was as efficient as that of fluticasone in alleviating symptoms. During remission of asthma, combined salmeterol and fluticasone propionate was probably better than fluticasone for control of symptoms.
出处
《国际儿科学杂志》
2013年第5期529-531,共3页
International Journal of Pediatrics
关键词
哮喘
沙美特罗替卡松气雾剂
学龄前儿童
Asthma
Combined salmeterol plus fluticasone aerosol
Preschool children
