摘要
目的探讨绝经后女性2型糠尿病(T2DM)患者性激素水平变化的特点。方法收集90例绝经后女性T2DM患者的空腹血糖(FPG)、空腹胰岛素(FPI)、血清雌二醇(E2)、促卵泡剌激素(FSH)、促黄体生成素(LH)、孕激素(P)、垂体泌乳素(PRL)及睾酮(T)等检测值,观察性腺激素的变化;根据胰岛素抵抗指数(HOMAIR)将所有研究对象分为胰岛素抵抗组(IR组)和无胰岛素抵抗组(Non-IR组),探讨绝经后女性T2DM性激素变化特点及其与胰岛素抵抗的关系。结果绝经后女性T2DM的E2、FSH、LH显著减低(P<0.05),PRL、T显著增高(P<0.05),P略降低,但差异无统计学(P>0.05);IR组与Non-IR组比较,E2减低(P<0.05),其余性激素差异无统计学(P>0.05)。结论绝经后女性T2DM患者性激素严重紊乱,且与胰岛素抵抗密切相关。
Objective To discuss the changes of hormone level in postmenopausal women with type 2 diabetes mellitus （ T2DM ）. Methods 90 cases of post - menopausal women with T2DM were collected in the study, and fasting plasma glucose （ FPG）, fasting insulin （ FPI ） , serum estradiol （ plasma estradiol, E2 ） , follicle - stimulating assassination hormone （ follicle - stimulating hor- mone, FSH ）, luteinizing hormone （ luteinizing hormone, LH ）, progesterone （ progesterone, P） , prolactin （ prolactin, PRL） and testoster- one （testosterone,T） were detected ;The changes of these gonadal hormones were observed and compared these values with normal values. The patients were divided into HOMA - IR group and Non - IR group according to the HOMA - IR and analyzed the changes of hormone level. Results E2, FSH, LH were significantly decreased ; PRL and T were significantly increased in case group than those in control group （ P 〈 0.05 ）. E2 were significantly decreased in HOMA - IR group than those in Non - IR group （ P 〈 0.05 ）. Conclusion This study shows that hormone of postmenopausal women patients with T2DM are serious sex disorders,hormone and insulin resistance is closely related.
出处
《宁夏医学杂志》
CAS
2013年第9期831-832,共2页
Ningxia Medical Journal
关键词
绝经
2型糖尿病
性激素
胰岛素抵抗
Menopause
Type 2 diabetes mellitus
Hormones
Insulin resistance
