摘要
目的探讨大Y、小Y染色体与精液质量及体外受精/卵泡浆内单精子注射(IVF/ICSI)助孕效果之间的关系。方法回顾638对夫妇行IVF/ICSI助孕治疗的不孕不育或不良孕产史夫妇的染色体核型,对比分析染色体核型正常组与大Y组、小Y组之间IVF/ICSI助孕后受精率、卵裂率、优质胚胎率、妊娠率、出生率、流产率等。结果 638对夫妇行IVF/ICSI助孕患者中双方染色体核型均正常者共518对,男方染色体为大Y女方染色体核型正常者52对,男方染色体为小Y女方染色体核型正常者17对。大Y、小Y染色体检出率分别为8.15%(52/638)、2.66%(17/638)。大Y/小Y染色体与精液参数的关系显示轻中度少弱精组小Y的检出率6.1%高于正常精液组的1.6%(P<0.05);重度、极重度少弱精组的大Y的检出率17.0%高于正常精液组的6.4%(P<0.05);无精子组小Y检出率6.1%亦高于正常精液组(P<0.05)。结论大Y和小Y染色体可引起男性少弱精、无精,对IVF/ICSI助孕效果有影响。
Objective To study the relationship between different Y chromosome abnormality with semen quality and quantity and IVF/ICSI outcomes. Methods The chromosome karyotype was analyzed for 638 infertile couples undergoing IVF/ICSI retrospective- ly, and relationship between different Y chromosome abnormality with semen quality and quantity and IVF/ICSI outcomes were study. Results Out of 638 infertile couples who underwent IVF/ICSI in our study, 518 with normal karyotype, the prevalence of big Y and small Y chromosomal were respectively 8.15% and 2.66%. The small Y chromosome was significant higher in mild to moderate oligo - asthenospermic patients than that in normal semen patients （6.1% vs. 1.6%, P 〈 0.05 ） ;the small Y chromosome was also higher in azoospermia patients than that in normal semen group （6.1% vs. 1.6% ,P 〈 0.05 ）. The big Y chromosome was higher in severe or very severe oligo - asthenospermic patients than that in normal semen patients （ 17% vs. 6.4% ,P 〈 0.05）. Conclusion The big or small Y chromosome karyotype is related to asthenospermia and azoospermia.
出处
《宁夏医学杂志》
CAS
2013年第9期805-807,共3页
Ningxia Medical Journal
