摘要
目的了解医院感染真菌菌株临床分布及耐药现状,以指导临床合理用药,为减少真菌感染提供试验依据。方法回顾性调查2010年1月至2012年12月医院住院患者发生真菌感染的相关资料及药敏试验结果,并对1 789例医院真菌感染进行分析。结果 3年间共检出院内真菌感染1 789例,总分离率为16.9%,2010~2012年真菌检出率分别为14.8%、16.3%、19.6%,真菌种类以假丝酵母菌为主,占90.9%,以白色假丝酵母菌最多,65.7%,其次是克柔假丝酵母菌144株和热带假丝酵母菌192株,比例分别为8.86%、11.8%。痰液、尿液、大便是检出真菌菌株最多的标本,构成比分别占76.7%,7.77%,6.04%,多发于老年患者。真菌感染患者主要来自呼吸科、老年科、ICU、神经内科、心血管内科等科室。体外药敏实验两性曲霉B、制霉菌素敏感率最高,分别为98.5%、97.9%,对5-氟胞嘧啶、氟康唑、伏立康唑、伊曲康唑的耐药率分别为25.7%、26.6%、35.1%、41.6%。结论假丝酵母菌是医院发生院内感染最常见的真菌,耐药性有增长趋势。应对分离菌株进行药敏试验,根据实验室的药敏试验结果指导临床合理。
Objective To investigate the clinical characters and drug resistance of infection fungal in nosocomial infection,and to provide the experimental evidence for reducing fungal infections.Methods The related clinical data and results of drug sensitivity tests of fungal infection in the Peoples Hospital islated from December 2010to December 2012were retrospectively analyzed,1 789 cases of nosocomial fungal infection in the hospital were analyzed.Results Totaly 1 789strains of nosocomial fungal infection were detected during stree year period,the total detection rate was 16.9%,the detection rate of fungi from 2010to 2012were 14.8%,16.3%,19.6%.The mian pathogen of invasive fungal infection was Candida spp（90.9%）.The most of them were Candida albicans（65.7%）,candida krysei was 144strais（8.86%）,Candida tropicalis was 192strais（11.8%.）,most fungi were found in sputum 76.7%,urine 7.77%andstool specimens 6.04%.It was more likely to affect the elderly.The patients with invasive fungal infections were mainly from respiratory department,senile,ICU department,neurology department,cardiovascular medicine department.There had a highest susceptibility rate to amphoterien B and enzyme bacteria according to drug sensitivity tests invitro,the drug susceptibility rate to amphoterien B and enzyme bacteria were 98.5%,97.9%.the drug resistant rate to 5-fluorocytosine,fluconazoie,voriconazol,ITCaconazole were 25.7%,26.6%,35.1%,41.6%.Conclusion Candida albicans been one of the most communpathogens proceed from senile patients and that drug resistanceiIncreasing nos）comial infection.usceptibility test should be conducted on isolates of fungus and its results will guide us to use drugs appropriately and prevent infection effectively in Clinic practice.
出处
《国际检验医学杂志》
CAS
2013年第18期2409-2410,2412,共3页
International Journal of Laboratory Medicine
关键词
院内感染
真菌
酵母菌属
抗药性
微生物
微生物敏感性试验
nosocomial infection
fungi
saccharomyces
drug resistance
microbial
microbial sensitivity tests
