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500例梅毒患者血清抗核抗体和抗心磷脂抗体检测结果分析 被引量:7

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摘要 目的研究梅毒患者血清抗核抗体(ANA)和抗心磷脂抗体(ACA)的产生和分布情况。方法试验组以血清梅毒螺旋体明胶颗粒凝集试验(TPPA)呈阳性的梅毒患者为研究对象,用快速血浆反应素试验(RPR)检测血清中的非特异性抗体,间接免疫荧光法(IIF)检测血清中的ANA,用酶联免疫吸附试验(ELISA)检测血清中的ACA。对照组采集健康体检的非梅毒患者血清样本,与试验组平行检测。结果试验组500例梅毒患者样本中,有152例ANA呈阳性,阳性率为30.4%,与RPR滴度的相关性为0.652;有325例ACA呈阳性,阳性率为65.0%,与RPR滴度的相关性为0.918;415例对照组的样本中,有49例ANA呈阳性,阳性率为11.8%,与试验组比较P值小于0.01,有18例ACA呈阳性,阳性率为4.3%,与试验组比较P值小于0.01。结论梅毒患者ANA阳性率较高,ACA的阳性率与RPR滴度有较好的相关性。
出处 《检验医学与临床》 CAS 2013年第18期2410-2411,共2页 Laboratory Medicine and Clinic
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