摘要
目的 研究中药山柰的混杂品种苦山柰KaempferiamarginataCarey的化学成分。 方法 利用色谱技术进行分离纯化 ,根据化合物的理化性质和光谱数据进行结构鉴定。结果 从苦山柰的根茎分得苦山柰萜醇 (1)、8(14) ,15 sanderacopimaradiene 1α ,9α diol (2 )、8(14) ,15 sanderacopimaradiene 1α ,6 β ,9α triol (3)、吉马酮 (4 )、对 甲氧基 肉桂酸乙酯 (5 )和正 十五烷 (6 )。结论 苦山柰萜醇 (1)为新二萜醇 ,化学结构为 8(14) ,15 isopimaradiene 6α ol。2 ,3和 4是首次从该植物中分得。
AIM To study the chemiacal constituents of the rhizomes of Kaempferia galanga L. (Zingiberaceae). METHODS Various chromatographic techniques were used to separate and purify. Their physico-chemical properties and spectral data were used to elucidate the structures. RESULTS Six compounds were isolated from the hexane extract of K.galanga . Their structures were identified as marginatol (1), 8(14),15-sanderacopimaradiene-1α,9α-diol (2), 8(14),15-sanderacopimaradiene-1α,6β,9α-triol (3), germacrone (4), trans -ethyl p -methoxycinnamate (5) and n -pentadecane (6) on the basis of spectral data (IR, MS, 1H- 1H , 13 C- 1H NMR, NOEs and HMBC). CONCLUSION Marginatol (1) is a new isopimarene diterpenoid and was elucidated as 8(14),15-isopimaradiene-6α-ol. Compounds 2, 3 and 4 were isolated for the first time from this plant.
出处
《药学学报》
CAS
CSCD
北大核心
2000年第10期760-763,共4页
Acta Pharmaceutica Sinica
基金
国家中医药管理局85攻关项目
关键词
苦山柰
姜科
二萜醇
苦山柰萜醇
化学成分
Kaempferia marginata Carey
Zingiberaceae
diterpenoids
marginatol