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类风湿关节炎患者外周血白介素-6的水平及其临床意义探讨 被引量：1

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摘要 目的检测类风湿关节炎(RA)患者外周血白介素-6(IL-6)的水平并探讨其与疾病活动性、功能状态、骨侵蚀、外周血炎性指标、血清自身抗体的相关关系。方法选取RA患者55例及健康对照者10名,记录临床资料及实验室指标,ELISA检测外周血IL-6水平,分析IL-6与临床及实验室指标的相关关系。结果 RA患者外周血IL-6水平为(137.7±102.2)pg/ml,明显高于健康对照组(6.6±2.9)pg/ml;RA患者外周血IL-6水平与晨僵持续时间、疼痛VAS评分、肿胀关节数(SJC)、压痛关节数(TJC)、DAS28、HAQ评分、PLT计数、ESR、抗CCP抗体及双手X片sharp评分呈正相关关系,但与疲乏VAS评分、PAG、CRP、RF、APF、AKA无明显相关性;中高度活动组及骨侵蚀组RA患者外周血IL-6水平明显增高。结论 RA患者外周血IL-6水平明显升高,并与疾病活动性、外周血炎性指标、骨侵蚀水平明显相关,提示IL-6参与了RA疾病发生发展及骨关节破坏的过程。
作者 商鹏 赵文鹏 刘莹 陈晨
机构地区 山西医学科学院山西大医院骨科 山西医科大学第二临床医学院风湿科
出处 《中国现代药物应用》 2013年第19期47-49,共3页 Chinese Journal of Modern Drug Application
关键词 类风湿关节炎 白介素-6 疾病活动性 骨侵蚀
分类号 R593.22 [医药卫生—内科学]
  • 相关文献

参考文献13

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二级参考文献11

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中国现代药物应用
2013年 第19期

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