摘要
目的观察阿托伐他汀辅助治疗对慢性充血性心力衰竭患者氨基末端脑钠肽前体(NTproBNP)水平及心功能的影响。方法 CHF患者80例随机分为观察组和对照组各40例,两组均按照心功能分级给予相同的基础治疗,观察组在此基础上加用阿托伐他汀20 mg/d,每晚口服。结果治疗后14 d治疗组总有效率显著高于对照组(P<0.05)。观察组患者NT-proBNP与治疗前比较,差异均有统计学意义(P<0.05,);对照组NT-proBNP与治疗前比较,差异无统计学意义(P>0.05)。治疗后14 d,观察组NT-proBNP与治疗前比较与对照组比较差异均有统计学意义(P<0.05,0.01)。结论阿托伐他汀辅助治疗CHF,可进一步改善心功能,降低NT-pro BNP水平。
Objective To observe the adjuvant treatment of atorvastatin on chronic congestive heart failure patients amino terminal pro-brain natriuretic peptide levels and cardiac function. Methods Two groups were in accordance with NYHA given the same basic treatment, observation group based on the use of atorvastatin 20 mg / d, orally night. Results After treatment, 14 clays treatment group was significantly higher （P〈0.05）. NT-proBNP observation group compared with before treatment compared with the control group were statistically significant differences （P〈0.05,0.01）. NT-proBNP control group compared with before treatment, the difference was not statistically significant （P〉 0.05）. Conclusion Atorvastatin adjuvant therapy CHF, lower NT- pro BNP levels.
出处
《中国现代药物应用》
2013年第18期8-10,共3页
Chinese Journal of Modern Drug Application
