摘要
膜内成骨是骨骼形成的重要方式,其受多条信号通路的调控,Notch信号通路是其中重要的一条。异常的Notch信号通路影响骨骼的形成。深入探讨Notch信号通路在膜内成骨中的作用机制,有利于揭示临床多种骨骼畸形,尤其是颅颌面骨发育异常的发生机制,提供新的治疗靶标。本文概述Notch信号通路对膜内成骨过程的调控。
Intramembranous ossification is regulated and affected by many signal pathways. Notch signaling pathway plays important roles in bone formation. Abnormal Notch signaling pathway leads to the bone deformities. Understanding the function of Notch signaling pathway in osteogenesis reveals mechanisms of various bone deformities, especially crani- omaxillofacial bone deformities. This article focuses on functions of Notch signaling pathway and its regulation on osteo- genesis.
出处
《中国实用口腔科杂志》
CAS
2013年第8期507-509,共3页
Chinese Journal of Practical Stomatology
基金
国家自然科学基金青年项目(10972142
81000451)
上海市卫生局青年科研项目(2010y142)
上海市教委优秀青年教师项目[沪教委人(2010)83]
关键词
NOTCH信号通路
膜内成骨
颅颌面畸形
Notch signaling pathway
intramembranous ossification
craniomaxillofacial deformities
