摘要
诱导多能干细胞(induced pluripotent stem cells,iPSCs)是通过向分化的体细胞转入特定的外源转录因子进行重编程,从而获得具有自我更新能力和多能性的细胞。iPSCs具有形成体内所有细胞类型的潜能,尤其是能以患者自身体细胞制备iPSCs,可用于特定疾病的治疗,规避了异体移植引发的免疫排斥风险以及伦理和法律冲突等问题,在基础研究和临床应用都有广阔的应用前景。目前,在重编程体细胞为iPSCs的过程中,由于细胞来源不同,所采用的基因组合以及转基因方式各不相同,获得的iPSCs具有潜在的致癌性等安全隐患,导致iPSCs的临床应用面临新的生命伦理挑战。
Induced pluripotent stem cells （iPSCs） are derived from somatic cells by ectopic expression of a few transcription factors that have the ability of self-renew indefinitely and to differentiate into all cell types of an organism. The generation of patient-specific iPSCs provides an invaluable resource for regenerative medicine that can circumvent both the practical and ethical concerns, such as immune rejection of all organ grafts, ethical and legal conflicts in embryonic stem cells （ESCs） study , etc. Therefore, iPSCs have received widespread attention in basic and clinical research and holds tremen- dous potential for pharmacologic and medical applications. Although the generation of iPSCs has been proved as a robust technology, there are potential carcinogenicity and safety risk remain to be addressed for iPSCs in the clinical applications as result of the iPSCs generation methods, the original cell types and optimal culture conditions during reprogramming process.
出处
《医学与哲学（A）》
北大核心
2013年第8期48-50,共3页
Medicine & Philosophy:Humanistic & Social Medicine Edition
关键词
诱导多能干细胞
胚胎干细胞
生命伦理
induced pluripotent stem cells, embryonic stem cells, bioethics
