摘要
目的探讨手术后咪唑安定镇痛的时机对术后疼痛发生的影响。方法 70例连续硬膜外麻醉下行择期腹部手术病人 ,单盲法随机分为A组 (手术结束硬膜外腔注射生理盐水 ) ,B组 (手术结束硬膜外腔注射咪唑安定 0 1mg/kg) ,C组 (病人术后出现疼痛时硬膜外腔内注射咪唑安定 0 1mg/kg)。观察镇痛效果、镇静效果、生命体征及副作用。结果B组镇痛效果与镇痛持续时间明显优于C组 ;C组镇痛效果仅略优于A组 ;B组镇静度与C组比较差异有显著意义 ;咪唑安定硬膜外用药对循环与呼吸功能影响较小 ,但头晕、嗜睡发生率明显升高。结论手术病人在疼痛出现之前镇痛 (超前镇痛 ) ,能够产生较为满意的镇痛效果 ;而疼痛出现后用药 ,其镇痛效果较差。
Objective To investigate the effect of preemptive analgesia with midazolam in epidural on postoperative pain. Methods 70 adult patients of abdominal surgery with epidural anesthesia were randomly allocated to three groups by single-blind method. Group A (control): The 0.9% saline 10ml was injected epidurally immediately after operation. Group B: The midazolam (0.1mg/kg, added NS to 10ml ) was injected in the epidural space immediately after operation (preemptive analgesia). Group C: The received midazolam (0.1mg/kg, added NS to 10 ml) epidurally when patients felt pain after operation. The Analgesia efficiency, sedation efficiency, life sign and side effect were observed. Results In group B, analgesia efficiency and the duration were significant superior to those of group C, and in group C they were only a little better than those of group A. Seadtion in group B had notable difference with that of group C. There was only a slight influence on respiratory and circulatory system after epidural administration of miadazolam. However, the occurauce of dizziness and lethargy were higher. Conclusion Preemptive analgesia could relieve post-operation pain effectively. Analgesia will be poor when given after pain having appeared.
出处
《贵州医药》
CAS
2000年第11期658-659,共2页
Guizhou Medical Journal
