摘要
目的探讨应用猪小肠黏膜下层生物补片治疗盆腔器官脱垂（POP）的临床效果。方法回顾性分析2012年3月至2013年3月在北京大学人民医院应用猪小肠黏膜下层生物补片行全盆底重建术治疗的15例POP定量（POP—Q）分度法Ⅲ度患者的临床资料，15例患者平均年龄59（39～82）岁。比较手术前、后POP—Q各指示点位置及生命质量相关问卷[盆底疾病生命质量影响问卷简表（PFIQ-7）、盆底功能障碍性疾病症状问卷简表（PFDI-20）及性生活质量问卷（PISQ-31）]分数，评估患者主观满意率、复发率及生命质量改善情况。结果15例患者平均随访时间9．9（3～15）个月；平均手术时间96（65～120）min；平均术中出血量159（50～500）ml。术后未发现切口感染、补片侵蚀及暴露。患者主观满意率为14／15，脱垂复发率为2／15。患者PFDI-20评分由术前平均87（56～124）分降至术后30（22～48）分，PFIQ-7评分由术前平均129（85～158）分降至术后24（18～48）分，PISQ-31评分由术前平均48（32～55）分升高至术后79（66～89）分，手术前、后分别比较，差异均有统计学意义（P〈0．05），9例患者术后恢复性生活。结论应用猪小肠黏膜下层生物补片行全盆底重建术治疗重度POP近期随访疗效满意，手术后生命质量及性生活质量提高明显，并发症少，但远期效果尚待随访观察。
Objective To study clinical efficacy of porcine-derived small intestinal subumcosa （Surgisis） in treatment of pelvic organ prolapse （POP）. Methods From Mar. 2012 to Mar. 2013, 15 patients with POP at more than m of POP quantitation （POP-Q） staging system undergoing pelvic reconstructive surgery with Surgisis in Peking University People＇s Hospital. The mean age was 59 years old （39 - 82）. The variable site of POP-Q staging system was compared between preoperative and postoperative status among those patients. Quality of life questionnaire of pelvic floor impact questionnaire （ PFIQ-7 ）, pelvic floor distress inventory short form （PFDI-20） and PISQ-31 were studied to evaluate subjective satisfaction, recurrence and the quality of life＇s improvement. Results All patients were followed up at mean of 9.9 months （3 - 15 months）, the mean time of surgery was 96 rains （65 - 120 rains）, the mean blood loss was 159 ml （50 -500 ml）. No infection and erosion was observed on those patients. The rate of subjective satisfaction was 14/15, the recun＇ence rate of prolapse was 2/15. Scoring system of PFDI-20 was from 87 （56 - 124） at operative status to 30 （22 -48） at postoperative status. PFIQ-20 was from 129 （85 - 158） at preoperative status to 24 （ 18 - 48） at postoperative status. PISQ-31 was from 48 （32 - 55 ） at preoperative status to 79 （66 - 89） at postoperative status, which all reached statistical difference （ all P 〈 0. 05 ）. Total 9 patients obtained satisfactox~~ sexual life. Conclusions The short-term clinical effect of pelvic reconstructive surgery with Surgisis was satisfied, quality of life and sexual life was improved, and less complication were observed. However, long-term clinical effect on patients should be warranted to follow up.
出处
《中华妇产科杂志》
CAS
CSCD
北大核心
2013年第8期575-578,共4页
Chinese Journal of Obstetrics and Gynecology
关键词
盆腔器官脱垂
小肠
肠黏膜
移植物
妇科外科手术
治疗结果
Pelvic organ prolapse
Intestine, small
Intestinal mueosa
Transplants
Gynecologic surgical procedures
Treatment outcome
