摘要
神经病理性疼痛是一种神经系统损伤引起的慢性疼痛,严重影响患者的生活质量。药物治疗仍是现用治疗神经病理性疼痛的主要方法。本文综述了现用于治疗神经病理性疼痛主要药物的分子药理机制及其临床运用特点,并在总结疼痛的发生机制的基础上对靶向治疗药物的研发进行了展望。
Neuropathic pain is a form of chro- nic pain caused by nervous lesions and signifi- cantly reduces patientff quality of life. Nowadays pharmacotherapy is still the main therapeutic paradigm. The article summarizes the underly- ing molecular pharmacologic mechanisms of the drugs used in the pharmacotherapy as well as their application characteristics in the clinical practice, and points out the perspective of the development of targeted drugs on the basis of e- lucidating the mechanisms of neuropathic pain.
出处
《中国临床药理学与治疗学》
CAS
CSCD
2013年第9期1076-1080,共5页
Chinese Journal of Clinical Pharmacology and Therapeutics
关键词
神经病理性疼痛
药物治疗
镇痛
综述
Neuropathic Pain~ Pharmaco- therapy~ Analgesic
Review
